Asit Pattnaik

Following a B.S. degree in Physics from Ravenshaw University in Cuttack, Odisha, India, I completed Master's Degree in Life Sciences from Jawaharlal Nehru University in New Delhi, India, and Ph.D in Virology from Griffith University, Australia. After completing post-doctoral research trainings at the University of California, Los Angeles and the University of Alabama at Birmingham, joined the faculty in the Department of Microbiology and Immunology at the University of Miami Medical School in 1992. In 2002, relocated to the University of Nebraska-Lincoln, where I am currently a Professor in the School of Veterinary Medicine and Biomedical Sciences and a member of the Nebraska Center for Virology. I conduct research on molecular biology and immunopathogenesis of RNA viruses.

icon-academic-capEducation

Ph D, Griffith University, 1984
MS, Jawaharlal Nehru University, 1978
BS, Ravenshaw University , 1976

icon-chat-userCourses

VBMS 852, Molecular Virology and Viral Pathogenesis, Fall 2022
VBMS 950, Medical Molecular Virology, Fall 2021

icon-documentPublications and Other Intellectual Contributions

Infectious defective interfering particles of VSV from transcripts of a cDNA clone, Cell
Identification of four complementary RNA species in Akabane virus-infected cells, J. Virology
A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus, Virology
Influence of N-Linked Glycosylation of Porcine Reproductive and Respiratory Syndrome Virus GP5 on Virus Infectivity, Antigenicity, and Ability to Induce Neutralizing Antibodies, J. Virology
Infectious clone-derived viruses from virulent and vaccine strains of porcine reproductive and respiratory syndrome virus mimic biological properties of their parental viruses in a pregnant sow model, Vaccine
Immune Evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involved glycoprotein 5 as well as glycoprotein 3., J. VIROLOGY, June 2011
RNAi Screening Reveals A Requirement for Host Cell Secretory Pathway in Infection by Diverse Families of Negative-Strand RNA Viruses, Proc. Natl. Acad. Sci. U.S.A.
Induction of Interferon and Interferon Signaling Pathways by Replication of Defective Interfering Particle RNA in Cells Constitutively Expressing Vesicular Stomatitis Virus Replication Proteins, J. Virology, May 2010
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes, Nature Immunology, January (1st Quarter/Winter) 2013
Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells, Journal of Virology
An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model., Vaccines , September 2019
Cells that express all five proteins of vesicular stomatitis virus from cloned cDNAs support replication, assembly and budding of defective interfering particles, Proc. Natl. Acad. Sci., U.S.A.
Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus, ANTIVIRAL RESEARCH, March 2018
Dose−Response Effects of 7‑Dehydrocholesterol Reductase Inhibitors on Sterol Profiles and Vesicular Stomatitis Virus Replication, ACS Pharmacology and Translational Science
Emerging Biomedical Applications of the Vesicular Stomatitis Virus Glycoprotein, ACS Omega, September 2022
Essential role for the dsRNA-dependent protein kinase, PKR, in innate immunity to viral infection, . Immunity
Glycosylation of minor envelope glycoproteins of PRRSV in infectious virus recovery, receptor interaction, and immune response, Virology, February 2011
hnRNP K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression. , J. Virology, September 2013
Host Cell Functions in Vesicular Stomatitis Virus Replication (Chapter 6), March 2015
Hypersusceptibility to vesicular stomatitis virus infection in dicer-deficient mice is due to impaired miR24 and miR93 expression, Immunity
Identification of four complementary RNA species in Akabane virus-infected cells, J. Virology
Inhibition of Zika virus replication by G-quadruplex-binding ligands, Molecular Therapy: Nucleic Acids, March 2021
Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication, Journal of Virology, October (4th Quarter/Autumn) 2020
Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites , Journal of Virology
Replication and amplification of defective interfering particle RNAs of vesicular stomatitis virus in cells expressing viral proteins from vectors containing cloned cDNAs, J. Virology

icon-business-chartResearch & Grants

Identification & Characterization of PRRSV Immunogenic Subunits using Viral Vectors, Univ of Minnesota, December 2004
PRRSV Self-Propagating Replicon, Natl Pork Board, October 2013
VSV RNA Transcription and Replication, DHHS-NIAID, December 2002
Analyses of Virulence & Attenuation Determinants of PRRSV using Reverse Genetics, Dept of Agriculture-NRICGP, September 2004
Development of a Broadly Protective Vaccine for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Internal, October 2014
Immune Response to PRRSV Glycoprote, Dept of Agriculture-AFRI, September 2009

icon-keynotePresentations

PRRSV Genes in Innate and Acquired Immune Response, USDA/University of Maryland, Beltsville
Host Cell Factors in VSV Replication, Institute of Life Sciences, Bhubaneswar, INDIA, Bhubaneswar, INDIA

icon-bookmark-starAwards & Honors

The Stanley Glaser Award, The Stanley Glaser Research Foundation, 1993
Sir JBS Haldane Honor Lecture, KIIT University School of Biotechnology, 2013

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