faculty
Work Beadle Center (BEAD) N133
Lincoln NE 68588-0664
US
Work 402-472-7468 On campus, dial 2-7468
My research program is focused on the biology and biochemistry of the Stabilin receptors and how they affect human physiology and disease. Due to their expression in liver and other tissues of the body, their contribution to extracellular matrix management and the catabolism of certain therapeutic drugs is significant in terms of metabolic half-life.

icon-academic-capEducation

  • BS, Brigham Young University, 1996
  • Ph D, Louisiana State University Health Sciences Center, 2001

icon-chat-userCourses

  • BIOC 435, Advanced Topics in Biochemistry; Glycobiology, Fall 2016
  • BIOC 431, Structure and Metabolism, Fall 2018
  • CHEM 831, Structure and Metabolism, Fall 2018
  • BIOC 431, Structure and Metabolism, Fall 2017
  • BIOC 431, Structure and Metabolism, Fall 2019

icon-documentPublications and Other Intellectual Contributions

  • Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified Antisense Oligonucleotides (ASOs), Nucleic Acids Research, April (2nd Quarter/Spring) 2016
  • Probing Structural Selectivity of Synthetic Heparin Binding to Stabilin Protein Receptors , Journal of Biological Chemistry, April (2nd Quarter/Spring) 2012
  • In vivo liver endocytosis followed by purification of liver cells by liver perfusion., Journal of visualized experiments : JoVE, November 2011
  • Endosomal Escape of ASOs internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation, Nucleic Acid Therapeutics, February 2018
  • Receptor mediated uptake of phosphorothioate antisense oligonucleotides in different cell types of the liver, Nucleic Acid Therapeutics, February 2018

icon-business-chartResearch & Grants

  • LMWH Clearance, DHHS-NHLBI, March 2016
  • Synthetic HS, Univ of North Carolina, June 2016

icon-keynotePresentations

  • Systemic clearance: Natural and synthetic glycosaminoglycan-based drugs cleared by the Stabilin family of receptors., CARB division, San Francisco, CA
  • The Stabilins are the Primary Scavenger Receptors for Phosphorothioate Antisense Oligonucleotides in Liver Sinusoidal Endothelial Cells, International Society for Hepatic Sinusoidal Research, Sydney Australia

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