faculty
Work Morrison Center (MOLR) 109
Lincoln NE 68583-0900
US
Work 402-472-1067 On campus, dial 2-1067
Following a B.S. degree in Physics from Ravenshaw University in Cuttack, Odisha, India, I completed Master's Degree in Life Sciences from Jawaharlal Nehru University in New Delhi, India, and Ph.D in Virology from Griffith University, Australia. After completing post-doctoral research trainings at the University of California, Los Angeles and the University of Alabama at Birmingham, joined the faculty in the Department of Microbiology and Immunology at the University of Miami Medical School in 1992. In 2002, relocated to the University of Nebraska-Lincoln, where I am currently a Professor in the School of Veterinary Medicine and Biomedical Sciences and a member of the Nebraska Center for Virology. I conduct research on molecular biology and immunopathogenesis of RNA viruses.

icon-academic-capEducation

  • Ph D, Griffith University, 1984
  • MS, Jawaharlal Nehru University, 1978
  • BS, Ravenshaw University , 1976

icon-chat-userCourses

  • VBMS 852, Molecular Virology and Viral Pathogenesis, Fall 2022
  • VBMS 950, Medical Molecular Virology, Fall 2021

icon-documentPublications and Other Intellectual Contributions

  • Infectious defective interfering particles of VSV from transcripts of a cDNA clone, Cell
  • Identification of four complementary RNA species in Akabane virus-infected cells, J. Virology
  • A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus, Virology
  • Influence of N-Linked Glycosylation of Porcine Reproductive and Respiratory Syndrome Virus GP5 on Virus Infectivity, Antigenicity, and Ability to Induce Neutralizing Antibodies, J. Virology
  • Infectious clone-derived viruses from virulent and vaccine strains of porcine reproductive and respiratory syndrome virus mimic biological properties of their parental viruses in a pregnant sow model, Vaccine
  • Immune Evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involved glycoprotein 5 as well as glycoprotein 3., J. VIROLOGY, June 2011
  • RNAi Screening Reveals A Requirement for Host Cell Secretory Pathway in Infection by Diverse Families of Negative-Strand RNA Viruses, Proc. Natl. Acad. Sci. U.S.A.
  • Induction of Interferon and Interferon Signaling Pathways by Replication of Defective Interfering Particle RNA in Cells Constitutively Expressing Vesicular Stomatitis Virus Replication Proteins, J. Virology, May 2010
  • Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes, Nature Immunology, January (1st Quarter/Winter) 2013
  • Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells, Journal of Virology
  • An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model., Vaccines , September 2019
  • Cells that express all five proteins of vesicular stomatitis virus from cloned cDNAs support replication, assembly and budding of defective interfering particles, Proc. Natl. Acad. Sci., U.S.A.
  • Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus, ANTIVIRAL RESEARCH, March 2018
  • Dose−Response Effects of 7‑Dehydrocholesterol Reductase Inhibitors on Sterol Profiles and Vesicular Stomatitis Virus Replication, ACS Pharmacology and Translational Science
  • Emerging Biomedical Applications of the Vesicular Stomatitis Virus Glycoprotein, ACS Omega, September 2022
  • Essential role for the dsRNA-dependent protein kinase, PKR, in innate immunity to viral infection, . Immunity
  • Glycosylation of minor envelope glycoproteins of PRRSV in infectious virus recovery, receptor interaction, and immune response, Virology, February 2011
  • hnRNP K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression. , J. Virology, September 2013
  • Host Cell Functions in Vesicular Stomatitis Virus Replication (Chapter 6), March 2015
  • Hypersusceptibility to vesicular stomatitis virus infection in dicer-deficient mice is due to impaired miR24 and miR93 expression, Immunity
  • Identification of four complementary RNA species in Akabane virus-infected cells, J. Virology
  • Inhibition of Zika virus replication by G-quadruplex-binding ligands, Molecular Therapy: Nucleic Acids, March 2021
  • Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication, Journal of Virology, October (4th Quarter/Autumn) 2020
  • Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites , Journal of Virology
  • Replication and amplification of defective interfering particle RNAs of vesicular stomatitis virus in cells expressing viral proteins from vectors containing cloned cDNAs, J. Virology

icon-business-chartResearch & Grants

  • Identification & Characterization of PRRSV Immunogenic Subunits using Viral Vectors, Univ of Minnesota, December 2004
  • PRRSV Self-Propagating Replicon, Natl Pork Board, October 2013
  • VSV RNA Transcription and Replication, DHHS-NIAID, December 2002
  • Analyses of Virulence & Attenuation Determinants of PRRSV using Reverse Genetics, Dept of Agriculture-NRICGP, September 2004
  • Development of a Broadly Protective Vaccine for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Internal, October 2014
  • Immune Response to PRRSV Glycoprote, Dept of Agriculture-AFRI, September 2009

icon-keynotePresentations

  • PRRSV Genes in Innate and Acquired Immune Response, USDA/University of Maryland, Beltsville
  • Host Cell Factors in VSV Replication, Institute of Life Sciences, Bhubaneswar, INDIA, Bhubaneswar, INDIA

icon-bookmark-starAwards & Honors

  • The Stanley Glaser Award, The Stanley Glaser Research Foundation, 1993
  • Sir JBS Haldane Honor Lecture, KIIT University School of Biotechnology, 2013

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